The story begins in Peregrine, Maine: the epicenter of superhuman activity in the United States. Sorrel Kaiwi, sister and mechanic by day, obscure superhero Saga by night, stays out of the spotlight, working in neighborhoods much like her own to protect others.That is, until the spotlight comes to her.Notorious supervillain Motus—thief, vandal, delinquent—approaches Saga one night and asks for her help. Supers across Peregrine are going missing, and his sidekick is among them. Some supers have become erratic: heroes committing crimes, villains crossing their own boundaries, politicians assassinated, and money stolen. Motus has tracked his sidekick to an impossibly secure facility belonging to a company called Remedium. In an epic race to stop Remedium, Saga is forced to revisit her past, question everything she thinks she knows about her family, and uncover the secrets behind the history of superhumans.