Domiciliary services provide care to patients who, due to their clinical condition, remain with specific care at home. Being the user’s residence a place not designed for health care, it offers additional risks to those of a hospital environment, requiring specific guidelines for this environment. Based on the analysis of knowledge and experiences of events and incidents in home care, four safe practices are proposed for this model of care, favoring coordinated work among its actors, with emphasis on risk management by providers, caregivers and patients in low complexity care. This descriptive observational study includes a bibliographic search of related information; the analysis of adverse events in low complexity home care that allows characterizing the main events; semi-structured surveys to professionals, patients, caregivers and leaders of the system, aimed at gathering knowledge and experiences on safe practices implemented.